Police conduct a manhunt for the Zodiac Killer, a serial killer who terrorized the San Francisco Bay Area during the late 1960s and early 1970s, taunting police with letters, bloodstained clothing, and ciphers mailed to newspapers.

• Paramount Pictures
• Warner Bros. Pictures
• Jake Gyllenhaal
• Mark Ruffalo
• Anthony Edwards
• Robert Downey Jr.
• Chloë Sevigny
• Elias Koteas
• John Carroll Lynch
• Brian Cox