Smallpox plagues Chief Winterhawk's tribe. He seeks cure from the white men, who in turn, in fear of getting the smallpox, kill two of his companions. Winterhawk comes back to kidnap a girl and her brother from the white men's settlement, and thus begins the chase...

• Charles B. Pierce Film Productions
• Howco International Pictures
• Michael Dante
• Leif Erickson
• Woody Strode
• Denver Pyle
• L.Q. Jones
• Elisha Cook Jr.
• Seamon Glass
• Dennis Fimple