The story follows three men—C.O. Darlington, C.O. Drudge, and C.O. Dusenberry (whose shared initials give the film its title)—who deceive their wives by faking illnesses to go on a secret vacation together.

• Vitagraph Company of America
• Harry Davenport
• Hughie Mack
• Eulalie Jensen
• Edwina Robbins
• William R. Dunn
• William Shea
• Ethel Corcoran
• Mary Anderson